Xenical diet pills are a medicine whose mechanism is based on preventing the absorption of fats entering the body. Thanks to the active element in the composition (lipase), fats are broken down to the phase in which the body absorbs them well. In this case, the fat molecules that have entered the body are excreted.
Tablets, according to reviews of those who lose weight, work in the gastrointestinal tract without dissolving in the blood. Taking them for a long time will not cause addiction in a person. It is prescribed for patients with diabetes mellitus, atherosclerosis, vascular pathologies and heart disease. Doctors recommend taking it to people with an increased BMI of 25 points and above. Before taking it is necessary to consult an endocrinologist.
Thanks to him, fewer calories are absorbed from the food consumed by a person. The active components of the drug do not remain in the blood, the patient does not get used to this remedy, and does not become dependent on it. Undigested fats are excreted with feces.
The first stage of treatment with tablets: stabilization of the initial weight, and the second stage: reducing it to 20%. This is a long acting drug. According to clinical studies, tablets begin to act within 24-48 hours. And they are excreted from the body in 48-72 hours.
Available in tablets. Active substances: gelatin, titanium dioxide, indigo carmine. The average cost of one package: 480 rubles.
Indications for use
It is used as a medicine for patients with severe obesity or overweight. Suitable for people who tend to be overweight. Can be used with hypoglycemic drugs (eg, insulin, etc.), combined with a low-calorie diet in patients with type 2 diabetes who are overweight or obese.
Instructions for use
Xenical, according to the instructions for use, is recommended to drink three times a day with meals. If a person eats more than three times, then tablets should be taken when the stomach receives the most food. With an increase in the dose, the effectiveness of the tablets does not increase.
How to take medicine for people at risk? It is not recommended to adjust dosages for elderly patients, as well as for patients with pathologies of the liver and kidneys. It is not used for the treatment of due to the lack of data on the efficacy and safety of the drug.
The first results appear after 14-21 days of using the drug. During the reception there is a ban on alcohol, carbonated drinks, sweet foods and fried foods. These products provoke a person to awaken his appetite and the amount of food eaten increases.
Particular attention in the process of nutrition should be given to fluids, which will quickly remove undigested fat from the body and improve bowel function. For these purposes, it is best to use water, mineral water without gas, kissels, juices. Additionally, taking the drug should be accompanied by physical activity, but without strength training. Strength training during treatment and diet leads to fatigue and exhaustion of the body.
Tablets are not recommended during pregnancy due to lack of data. Toxicity tests have been conducted on animals, but doctors do not deny that there is no evidence of how pills can affect a woman's body. Not recommended for lactation.
The active substance of the drug does not interact with alcoholic beverages. This is confirmed by multiple medical studies.
Contraindications
According to medical research, the tablets are considered safe and well tolerated by patients, but still have a number of contraindications. It is forbidden to take it to pregnant and lactating women. The medicine is contraindicated in the pathology of the gallbladder and the syndrome of reduced intestinal absorption.
Treatment with the drug for weight loss "Xenical" should be carried out with caution and under the supervision of a doctor for patients with bulimia, kidney pathologies and diabetics. Do not take it while self-medicating. If the patient's weight is within the normal range or less, then the probability of the disease is high.
Side effects
Despite the high efficiency of the drug, it has a number of contraindications. Often taking medication, complains of indigestion, feels discomfort after taking the pills. The consistency of feces changes, it becomes more oily, and intestinal motility becomes stronger.
Basically, these unpleasant phenomena haunt patients only during the first 8 weeks of admission, then they become smaller and disappear. With a low-calorie diet, it is important that the patient does not eat less than 15 grams of fat per meal, and the maximum amount of fat allowed per day is 45 grams.
There are allergic reactions: itching, angioedema, rash, urticaria. In rare cases, patients complain of the onset of migraines. As you adapt to the "new way of life", migraines disappear. Sometimes there are pains in the lower back when the patient starts taking the pills, at this time he is more susceptible to ARVI and acute respiratory infections.
results
Doctors note that patients who took the pills had greater weight loss than those people who followed a low-calorie diet. These results are confirmed by clinical studies.
The effect appeared after 14 days of use, the weight gradually decreased within six months to a year of taking the drug. In addition, in the course of treatment, an improvement in the risk factors accompanying
In addition, the drug does not allow you to gain weight again. Out of 100% of cases: 50% of people gain 25% of the amount of weight loss, 25% of people continue to lose weight, and another 25% of patients do not gain weight after the end of the intake.
Drug analogues
Like many drugs on the pharmaceutical market, the drug has a number of analogues, with a similar effect, but different in composition, manufacturer and price.
- Listaz. Active ingredient: orlistat and gum arabic. Gum arabic binds up to 50% of fats that enter the body. This analogue of the drug is cheaper, it costs about 750 rubles per pack. Release form: tablets.
- Orthosoten. He appeared in pharmacy chains in 2009 and became more affordable and the most similar generic Xenical in action. Active ingredients: orlistat and microcrystalline cellulose. The cost starts from 550 rubles per pack.
- Reduxin. Mechanism of action: effect on the brain, the brain suppresses hunger and due to this, the amount of food consumed is reduced. Weight slowly goes away by 500-1 thousand grams in 7 days. It takes a long time to be effective. Active substance: . Contraindicated in liver and kidney failure, mental illness. Not recommended for alcohol and nicotine addiction.
Xenical- an inhibitor of gastrointestinal lipases, which prevents the body from absorbing some of the fat contained in the foods eaten. Xenical is used in the treatment of obesity, in particular to reduce and maintain body weight in combination with a low-calorie diet. Xenical can also be used in cases not covered in this review article.
What to discuss with your doctor before taking xenical?
Never take Xenical without first consulting your doctor in the following cases:
With chronic malabsorption syndrome (reduced absorption)
With diseases of the gallbladder.
Xenical is contraindicated in people suffering from the diseases listed above.
Before taking Xenical, be sure to consult your doctor if you
Are you suffering from kidney stone disease?
You suffer from diabetes
Are you suffering from anorexia or bulimia?
Are you taking any other weight loss supplements?
You are taking sandimmun (sandimmun, neoral).
In these cases, Xenical should not be taken (or the dosage should be reduced or the medication should be taken under medical supervision).
According to the FDA (Food and Drug Administration), Xenical is Category B. This means that Xenical is not expected to harm the health and development of an unborn child. However, this medicine is not recommended to be taken during pregnancy without first consulting a doctor.
It is not known whether Xenical passes into breast milk, so if you are breastfeeding, you should also consult your doctor before taking Xenical.
How to take Xenical correctly?
Xenical should be taken in full accordance with the instructions or instructions of the doctor. If you do not understand the instructions, ask your pharmacist, nurse or doctor for help.
Each tablet should be taken with a full glass of water.
Xenical is usually taken with each meal containing fat, during meals or no later than one hour after meals, 120 mg 3 times a day.
Xenical should only be taken with a meal in which fat provides no more than 30% of the calories.
Daily intake of fats, carbohydrates and proteins should be distributed among the three main meals. Since Xenical reduces the absorption of certain fat-soluble vitamins, patients should take multivitamin preparations containing fat-soluble vitamins to ensure adequate intake.
It is allowed to skip taking Xenical if a meal was skipped or the food did not contain fat.
If Xenical is taken with a very high-fat meal, the risk of side effects and digestive upset increases.
Never exceed the prescribed dose of medication. Exceeding the standard dose (120 mg 3 times a day) does not lead to additional weight loss.
Xenical may decrease the absorption of certain fat-soluble vitamins. To provide the body with essential nutrients, a doctor often prescribes multivitamin supplements containing vitamins D, E, K, and beta-carotene. Such vitamin supplements should be taken once a day, at least two hours before or after taking Xenical. Xenical should be stored at room temperature in a cool, dry place.
What happens if you miss a medication?
The missed dose should be taken within an hour after a meal. If more than one hour has passed since a meal, skip Xenical and take your next dose as usual. Never take a double dose to catch up.
Xenical can be skipped if a meal was skipped or the food did not contain fat.
What are the possible side effects of Xenical?
Stop taking Xenical immediately and seek medical attention if you experience an unusual allergic reaction, the manifestations of which are shortness of breath, swelling of the lips, tongue or face, as well as a rash, etc.
Other, less serious side effects appear more frequently. Continue taking your medicine, but talk to your doctor if you experience any of the following:
Oily discharge from the rectum;
Emission of gases;
Imperative urge to defecate;
Steatorrhea;
Increased bowel movements;
Fecal incontinence
Orange or brown oily discharge in the stool.
The changes in normal stools listed above are a natural result of blocking fat and indicate the effectiveness of Xenical. As a rule, these phenomena are transient and occur in the first 3 months of treatment, when the fat content in food exceeds 30%.
It is also possible that other side effects not listed in this article may occur. If you notice an unusual or particularly unpleasant side effect, contact your doctor.
Nikochka
It’s good to talk to those who have a couple of extra kilos, and if someone has 15-20, then what should they do, no diet will help you lose that much weight. And Xenical not only removes excess fats from the body, but also teaches a person to eat healthy, I lost 15.5 kg in five months of taking it, and now I feel quite healthy
Katya, do you know that after 30, the metabolism slows down naturally? and losing weight is not as easy as it used to be. Here strength is not strength, but natural causes, for example, I didn’t eat anything particularly much and harmfully, but didn’t lose weight, only against the background of xenical weight and began to go away ... But I can’t eat at all, sorry, I still want to live
Yana11
Agree. Sometimes, unfortunately, products are not products, but with a huge weight, this is not a solution to the problem. When you want to lose 5 kg, then you can change your diet, go to the gym, etc. But when you gain 25 kilos of excess weight, unfortunately, that's all - like a dead poultice! Xenical was prescribed by an endocrinologist, slowly but surely, she lost 19 kg with him in 5 months, so I'm already at the finish line
You have to endure a brutal appetite) I recommend learning to get high from hunger: when you feel hungry - drag yourself that every minute you lose weight and become a princess! Or think like this: I'll eat, well, it's 20 minutes or less, and then what? Move mentally to the moment after eating - there is no longer a buzz, and your kilos have not left.
I drank Xenical for a very long time, a good thing, it helped, there are no bad consequences. When you go to the toilet, you can even see how little yellow droplets of fat come out.Miranda
With a brutal appetite, Xenical also helps to fight, it is somehow easier to give up something harmful in the diet when you see what exactly it is. But with the reasons for such an appetite, you need to figure out what exactly you are eating, at what moments you start to eat a lot. Look at the Health program, there was a lot about losing weight on YouTube, you can find the linkTraveler
Well, what's the problem, right now is the time to start losing weight, while there is still time before the New Year. This is not a matter of one day, if you really want to lose weight without harm to the body and for good - visit a nutritionist, consult.
Traveler
Yes, the nutritionist advised me Xenical. I had to lose quite a lot, more than 15 kg, and diets somehow didn’t help much, not to say that they didn’t help at all. And on Xenical, the excess weight began to go away quite cheerfully, especially at the beginning, then the process was already slower, but I was already determined to lose weight, so I didn’t leave the race)
Summer! Sea! Beach!
Is it hard to just stop eating fatty foods? then no xenical will be needed. my aunt drank xenical only because she could not refuse any kind of fat and jelly, pork kebab every weekend, etc. "joys". seems to have lost some weight. but when I normally took up weight loss and reviewed the diet (and its quantity) - I threw off 20 kg without any pills. and she is over 30 years old.
Innusha
I also took Xenical for 3 months, and lost as much as 10 kg. Now I have 70 kg, and it was 80, with a very average stature .... At the same time, before, only with diets, it was not possible to achieve, and most importantly, to keep the result. Not everyone is so strong-willed, but Xenical really disciplines in terms of healthy eating. And rightly they write here that after 30 it is already difficult to lose weight only with the help of diets and sports, the metabolism is not the same already ... And Xenical helped me a lot, a very good impression about this drug.
Genrieta
Sausages in principle are not a very healthy food. I have been following food for a long time. Well, from 70 kg I lost weight to 67 and that's it. The weight is up. Stayed for half a year. I'm taking Xenical now. Total 64kg The drug really helps. And willpower has nothing to do with it. You can strain and only drink kefir and chew apples. Lose weight. And then get treated. Great display of character! And here health remains normal, without consequences.
Xenical is a potent, specific and reversible inhibitor of gastrointestinal lipases with a long lasting effect. Its therapeutic effect is carried out in the lumen of the stomach and small intestine and consists in the formation of a covalent bond with the active serine site of gastric and pancreatic lipases. The inactivated enzyme loses its ability to break down dietary fats in the form of triglycerides into absorbable free fatty acids and monoglycerides. Because undigested triglycerides are not absorbed, the resulting decrease in calorie intake leads to weight loss. Thus, the therapeutic effect of the drug is carried out without absorption into the systemic circulation.
Judging by the results of fat content in the feces, the effect of orlistat begins 24-48 hours after ingestion. After discontinuation of the drug, the fat content in the feces after 48-72 hours usually returns to the level that occurred before the start of therapy.
Efficiency
Patients with obesity
In clinical studies, patients taking orlistat experienced greater weight loss compared to patients on diet therapy. Weight loss began already within the first 2 weeks after the start of treatment and lasted from 6 to 12 months, even in patients with a negative response to diet therapy. Over the course of 2 years, there was a statistically significant improvement in the profile of metabolic risk factors associated with obesity. In addition, compared with placebo, there was a significant reduction in body fat. Orlistat is effective in preventing re-gain of body weight. Re-gaining of body weight, no more than 25% of the lost, was observed in about half of the patients, and in half of these patients, re-gaining of body weight was not observed or even its further decrease was noted.
Patients with obesity and type 2 diabetes
In clinical studies lasting from 6 months to 1 year, patients with overweight or obesity and type 2 diabetes mellitus taking orlistat experienced greater weight loss compared to patients treated with diet therapy alone. Weight loss occurred mainly due to a decrease in the amount of fat in the body. It should be noted that before the start of the study, despite the use of hypoglycemic agents, patients often had insufficient glycemic control. However, with orlistat therapy, a statistically and clinically significant improvement in glycemic control was observed. In addition, against the background of orlistat therapy, a decrease in doses of hypoglycemic agents, insulin concentrations, and a decrease in insulin resistance were observed.Reducing the risk of developing type 2 diabetes in obese patients
In a 4-year clinical study, orlistat was shown to significantly reduce the risk of developing type 2 diabetes (by approximately 37% compared with placebo). The rate of risk reduction was even greater in patients with baseline glucose intolerance (approximately 45%). The orlistat group experienced more significant weight loss compared to the placebo group. Maintenance of body weight at a new level was observed throughout the entire study period. Moreover, compared with placebo, patients treated with orlistat showed a significant improvement in their metabolic risk factor profile.
Pubertal obesity
In a clinical study lasting 1 year in obese adolescents, when taking orlistat, a decrease in body mass index was observed compared with a placebo group, where there was even an increase in body mass index. In addition, patients in the orlistat group showed a decrease in fat mass, as well as waist and hip circumference, compared with the placebo group. Also, in patients treated with orlistat therapy, there was a significant decrease in diastolic blood pressure compared with the placebo group.
Preclinical safety data
According to preclinical data, no additional risks for patients regarding the safety profile, toxicity, genotoxicity, carcinogenicity and reproductive toxicity have been identified. Animal studies have also shown no teratogenic effect. Due to the absence of a teratogenic effect in animals, it is unlikely to be detected in humans.
Pharmacokinetics
Suction
In volunteers with normal body weight and obesity, systemic exposure to the drug is minimal. After a single oral dose of the drug at a dose of 360 mg, unchanged orlistat in plasma could not be determined, which means that its concentrations are below the level of 5 ng / ml.
In general, after taking therapeutic doses, it was possible to detect unchanged orlistat in plasma only in rare cases, while its concentrations were extremely low (<10 нг/мл или 0.02 мкмоль). Признаки кумуляции отсутствовали, что подтверждает, что всасывание препарата минимально.
Distribution
V d cannot be determined, since the drug is very poorly absorbed. In vitro, orlistat is more than 99% bound to plasma proteins (mainly lipoproteins and albumin). In minimal amounts, orlistat can penetrate red blood cells.
Metabolism
Judging by the data obtained in the experiment on animals, the metabolism of orlistat is carried out mainly in the intestinal wall. In a study in obese individuals, it was found that approximately 42% of the minimum fraction of the drug that undergoes systemic absorption falls on two main metabolites - M1 (four-membered hydrolyzed lactone ring) and M3 (M1 with a cleaved N-formilleucine residue).
Molecules M1 and M3 have an open b-lactone ring and inhibit lipase extremely weakly (respectively, 1000 and 2500 times weaker than orlistat). Given this low inhibitory activity and low plasma concentrations (average 26 ng/mL and 108 ng/mL, respectively) after therapeutic doses, these metabolites are considered to be pharmacologically inactive.
breeding
Studies in individuals with normal and overweight have shown that the main route of elimination is the excretion of unabsorbed drug with feces. Approximately 97% of the administered dose was excreted in the faeces, with 83% being excreted as unchanged orlistat.
The cumulative renal excretion of all substances structurally related to orlistat is less than 2% of the administered dose. The time to complete elimination of the drug from the body (with feces and urine) is 3-5 days. The ratio of orlistat excretion pathways in volunteers with normal and overweight was the same. Both orlistat and the metabolites M1 and M3 may be excreted in the bile.
Pharmacokinetics in special clinical groups
Plasma concentrations of orlistat and its metabolites (M1 and M3) in children do not differ from those in adults when comparing the same doses of the drug. The daily excretion of fat in the feces was 27% of the intake with food with orlistat therapy and 7% with placebo.
Release form
Hard gelatin capsules, No. 1, turquoise, opaque; on the body there is an inscription in black "XENICAL 120", on the cap - "ROCHE"; the contents of the capsules are white or almost white pellets.
Excipients: talc - 0.24 mg.
* The composition of the pellets: microcrystalline cellulose - 93.6 mg, sodium carboxymethyl starch (primogel) - 7.2 mg, povidone K-30 - 12 mg, sodium lauryl sulfate - 7.2 mg.
The composition of the capsule shell: gelatin, indigo carmine, titanium dioxide.21 pcs. - blisters (1) - packs of cardboard.
21 pcs. - blisters (2) - packs of cardboard.
21 pcs. - blisters (4) - packs of cardboard.Dosage
Long-term therapy in obese or overweight patients, including those with obesity-associated risk factors, in combination with a moderately hypocaloric diet in adults and children over 12 years of age, the recommended dose of orlistat is one 120 mg capsule with each main meal (during meal time or no later than one hour after the meal).
In combination with hypoglycemic drugs (metformin, sulfonylurea derivatives and / or insulin) or a moderately hypocaloric diet in overweight or obese patients with type 2 diabetes mellitus: in adults, the recommended dose of orlistat is one 120 mg capsule with each main meal (during meal time or no later than one hour after the meal).
If a meal is skipped or if the food does not contain fat, then Xenical can also be skipped.
The drug should be taken in combination with a balanced, moderately low-calorie diet containing no more than 30% of calories in the form of fat. The daily intake of fats, carbohydrates and proteins must be divided into three main meals.
The efficacy and safety of Xenical in patients with impaired liver and / or kidney function, as well as in elderly and pediatric patients (under 12 years of age) have not been studied.
Overdose
In clinical studies in people with normal body weight and obese patients, single doses of 800 mg or multiple doses of 400 mg 3 times / day for 15 days were not accompanied by the appearance of significant adverse events. In addition, obese patients have experience with the use of orlistat 240 mg 3 times / day for 6 months, which was not accompanied by a significant increase in the frequency of adverse events.
In cases of overdose of the drug Xenical, either no adverse events were reported, or adverse events did not differ from those observed when taking the drug at therapeutic doses.
In the event of a severe overdose of Xenical, it is recommended to observe the patient for 24 hours. Based on human and animal studies, any systemic effects that could be associated with the lipase-inhibiting properties of orlistat should be rapidly reversible.
Interaction
There were no interactions with amitriptyline, atorvastatin, biguanides, digoxin, fibrates, fluoxetine, losartan, phenytoin, oral contraceptives, phentermine, pravastatin, warfarin, nifedipine GITS (Gastrointestinal Therapeutic System), and slow-release nifedipine, sibutramine, or alcohol (based on drug interaction studies). However, it is necessary to monitor the INR indicators during concomitant therapy with warfarin or other oral anticoagulants.
When taken simultaneously with Xenical, there was a decrease in the absorption of vitamins D, E and betacarotene. If multivitamins are recommended, they should be taken at least 2 hours after taking Xenical or at bedtime.
With the simultaneous administration of Xenical and cyclosporine, a decrease in plasma concentrations of cyclosporine was noted, therefore, more frequent determination of plasma cyclosporine concentrations is recommended while taking cyclosporine and Xenical.
With oral administration of amiodarone during therapy with Xenical, a decrease in the systemic exposure of amiodarone and deethylamiodarone (by 25-30%) was noted, however, due to the complex pharmacokinetics of amiodarone, the clinical significance of this phenomenon is not clear. The addition of Xenical to long-term amiodarone therapy may reduce the therapeutic effect of amiodarone (no studies have been conducted).
Simultaneous administration of Xenical and acarbose should be avoided due to the lack of data from pharmacokinetic studies.
With the simultaneous administration of orlistat and antiepileptic drugs, cases of seizures have been observed. A causal relationship between the development of seizures and orlistat therapy has not been established. However, patients should be monitored for possible changes in the frequency and/or severity of seizures.
Side effects
Clinical Study Data
The following categories are used to describe the frequency of adverse reactions: very often (≥1/10), often (≥1/100,<1/10), нечасто (≥1/1000, <1/100), редко (≥1/10000, <1/1000) и очень редко (<1/10000), включая отдельные случаи.
Adverse reactions to orlistat arose mainly from the gastrointestinal tract and were due to the pharmacological action of the drug, which prevents the absorption of dietary fats. Very often, phenomena such as oily discharge from the rectum, gas with some discharge, imperative urge to defecate, steatorrhea, increased defecation, loose stools, flatulence, pain or discomfort in the abdomen were noted.
Their frequency increases with increasing fat content in the diet. Patients should be informed about the possibility of adverse reactions from the gastrointestinal tract and taught how to eliminate them by better dietary compliance, especially in relation to the amount of fat contained in it. The use of a low-fat diet reduces the likelihood of gastrointestinal side effects and thus helps patients control and regulate their fat intake.
As a rule, these side reactions are mild and transient. They occurred in the early stages of treatment (in the first 3 months), and most patients had no more than one episode of such reactions.
In the treatment with Xenical, the following adverse events from the gastrointestinal tract often occur: “soft” stools, pain or discomfort in the rectum, fecal incontinence, bloating, damage to the teeth, damage to the gums.
It was also noted very often: headaches, infections of the upper respiratory tract, influenza; often: lower respiratory tract infections, urinary tract infections, dysmenorrhea, anxiety, weakness.
In patients with type 2 diabetes, the nature and frequency of adverse events were comparable to those in people without diabetes with overweight and obesity. The only new adverse events in patients with type 2 diabetes were hypoglycemic conditions, which occurred with a frequency of >2% and an incidence of ≥1% compared with placebo (which could result from improved carbohydrate metabolism compensation), and often - bloating.
In the 4-year clinical study, the overall safety profile did not differ from that obtained in the 1- and 2-year studies. At the same time, the overall incidence of adverse events from the gastrointestinal tract decreased annually over a 4-year period of taking the drug.
Post-marketing surveillance
Rare cases of allergic reactions are described, the main clinical symptoms of which were itching, rash, urticaria, angioedema, bronchospasm and anaphylaxis.
Very rare cases of bullous rash, increased activity of transaminases and alkaline phosphatase, as well as individual, possibly serious, cases of hepatitis have been described (a causal relationship with taking Xenical ® or pathophysiological mechanisms of development have not been established).
With the simultaneous appointment of the drug Xenicali anticoagulants, there have been cases of a decrease in prothrombin, an increase in the values of the international normalized ratio (INR) and unbalanced anticoagulant therapy, which led to a change in hemostatic parameters.
Cases of rectal bleeding, diverticulitis, pancreatitis, cholelithiasis, and oxalate nephropathy have been reported (frequency unknown).
With the simultaneous administration of orlistat and antiepileptic drugs, there have been cases of seizures (see section "Interaction with other drugs").
Indications
- long-term therapy of obese patients or overweight patients, incl. having obesity-associated risk factors, in combination with a moderately low-calorie diet;
- in combination with hypoglycemic drugs (metformin, sulfonylurea derivatives and / or insulin) or a moderately hypocaloric diet in overweight or obese patients with type 2 diabetes mellitus.
Contraindications
- chronic malabsorption syndrome;
- cholestasis;
- hypersensitivity to the drug or any other components contained in the capsule.
Application features
Use during pregnancy and lactation
In studies of reproductive toxicity in animals, the teratogenic and embryotoxic effect of the drug was not observed. In the absence of a teratogenic effect in animals, a similar effect in humans should not be expected. However, due to the lack of clinical data, Xenical should not be given to pregnant women.
The excretion of orlistat in breast milk has not been studied, so it should not be taken during breastfeeding.
special instructions
Xenical is effective in terms of long-term weight control (weight loss and maintenance at a new level, prevention of re-gain of body weight). Treatment with Xenical leads to an improvement in the profile of risk factors and diseases associated with obesity, including hypercholesterolemia, type 2 diabetes mellitus, impaired glucose tolerance, hyperinsulinemia, arterial hypertension, and to a decrease in visceral fat.
When used in combination with hypoglycemic drugs such as metformin, sulfonylurea derivatives and / or insulin in patients with type 2 diabetes mellitus who are overweight (body mass index (BMI) ≥28 kg / m 2) or obese (BMI ≥30 kg / m 2), Xenical in combination with a moderately hypocaloric diet provides an additional improvement in the compensation of carbohydrate metabolism.
In clinical studies, in most patients, the concentrations of vitamins A, D, E, K and betacarotene during four years of orlistat therapy remained within the normal range. A multivitamin may be prescribed to ensure adequate intake of all nutrients.
The patient should receive a balanced, moderately low-calorie diet containing no more than 30% of calories in the form of fat. A diet rich in fruits and vegetables is recommended. The daily intake of fats, carbohydrates and proteins must be divided into three main meals.
The likelihood of adverse reactions from the gastrointestinal tract may increase if Xenical is taken on the background of a diet rich in fats (for example, 2000 kcal / day, of which more than 30% are in the form of fat, which equals approximately 67 g of fat). Daily fat intake should be divided into three main meals. If Xenical is taken with a meal that is very rich in fat, the likelihood of gastrointestinal reactions is increased.
In patients with type 2 diabetes, weight loss during treatment with Xenical is accompanied by an improvement in carbohydrate metabolism compensation, which may allow or require a dose reduction of hypoglycemic drugs (for example, sulfonylurea derivatives).
In the fight against extra centimeters at the waist, all means are good! Determined girls train to exhaustion in gyms, starve themselves, insert gold earrings into biologically active points on their ears. All with one goal - to get rid of unnecessary kilograms. Some ladies prefer an easier way - the use of special pills. In the list of those, Xenical is in demand for weight loss.
What is Xenical and what is it used for
For a long time, Xenical, manufactured in Switzerland, has been a leader among weight loss products.
Xenical - pills for weight loss and the treatment of obesity. They act on the digestive system, blocking the absorption of about one-third of the fat taken from food.
Its action is based on the blocking of lipase, that is, an enzyme that promotes the breakdown of fats to a state where they are easily absorbed. In simple terms, Xenical when losing weight does not allow the body to absorb them.
As a result of the intake, the body does not absorb about 30% of the fat absorbed by a person - it is excreted along with feces. To compensate for its shortage, internal reserves are used. However, it would be naive to believe that this drug alone will help reduce body weight. Its reception must be combined with a low-calorie diet. A reduced calorie diet will also minimize the occurrence of side effects.
According to the instructions for use, Xenical is intended for the treatment of obesity in combination with a calorie-restricted diet, as well as to reduce the risk of regaining weight that has already been lost.
The main ingredient in diet pills is Orlistat, which is classified as a lipase inhibitor. According to the description of the manufacturers, it works “magic” in the intestinal tract, destroys “extra” fat so that the body does not digest and store it.
Orlistat actually inhibits pancreatic lipase, the enzyme responsible for breaking down triglycerides in the gut. Thus, the weight loss drug prevents the conversion of triglycerides into free fatty acids that the body absorbs. The makers of Xenical claim that their amazing weight loss drug can significantly reduce—namely, by 30%—the amount of fat absorbed into the bloodstream, provided the patient takes the standard prescription dose of 120 mg, before meals, three times a day.
This means that it can process about 600 calories from daily digestion. Losing 600 calories per day will result in a loss of about 0.5 kg per week.
Contraindications
Xenical is contraindicated:
- suffering from diseases of the biliary and biliary tract;
- those with chronic intestinal malabsorption;
- during childbearing and breastfeeding;
- under 18 years old.
People with:
- nephrolithiasis;
- diabetes mellitus;
- anorexia or bulimia;
- when taking any other means for weight loss;
- when using sandimmun or neoral.
In addition to all of the above, Xenical reduces the absorption of fat-soluble vitamins when losing weight. After the consultation, the doctor will be able to tell you if you need to take any additional vitamins. In any case, a visit to the endocrinologist before taking this drug will not be superfluous!
Pay special attention when using Xenical:
Weight loss may also affect the dose of medications taken for other illnesses (such as high cholesterol or diabetes). Be sure to discuss these and other medications you are taking with your doctor. Weight loss means that a dose adjustment of these drugs is needed.
To get the most out of your treatment with this drug, follow the diet your doctor has prescribed. As with other weight management programs, excessive fat and calorie intake will reduce the effect of weight loss.
This medicine may cause harmless changes in the intestines, due to the release of unprocessed fat. The likelihood of this will increase if you take Xenical with a high fat content. In addition, daily fat intake should be evenly distributed between the three main meals, because if this drug is taken with a very high-fat meal, the likelihood of changes in the gastrointestinal tract will increase.
Xenical is not intended for use in children.
Interaction of the drug with other drugs
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including those available without a prescription.
This is important because using more than one drug at the same time can increase or decrease the effect.
Xenical can change actions:
- Anticoagulants(for example, warfarin). You may need a doctor to monitor blood clotting;
- Cyclosporine. Simultaneous use with cyclosporine is not recommended, but if you are taking cyclosporine, take it 3 hours before or after Xenical. You may need your doctor to monitor your blood levels of ciclosporin more frequently than usual;
- Levothyroxine sodium. Cases of hypothyroidism or decreased control of hypothyroidism may occur. If you are taking levothyroxine, take it at least 4 hours before or after;
- Amiodarone. Discuss the use of the drug with your doctor.
Xenical reduces the absorption of certain fat-soluble nutrients, especially beta-carotene and vitamin E. Because of this, follow your doctor's advice and eat a well-balanced diet rich in fruits and vegetables. Also take a multivitamin.
Because this drug interferes with the absorption of certain vitamins (fat-soluble vitamins including A, D, E, K), a daily multivitamin supplement containing these nutrients is recommended. Take a multivitamin 2 hours before or 2 hours after taking Xenical (for example, at bedtime).
Xenical with food and drink
Diet pills are taken immediately before, on time or 1 hour after meals. Capsules should be swallowed with water.
Pregnancy and lactation
Weight loss has no potential benefit for the pregnant woman and may harm the unborn child.
Do not breastfeed your baby while taking it as it is not known if Xenical passes into breast milk.
How to take Xenical for weight loss
Remember that you need to take Xenical for weight loss correctly, exactly as prescribed by the doctor. If you are unsure about something, ask your doctor or pharmacist for advice. The usual dose of Xenical for weight loss is one 120 mg capsule taken with each of the three main meals throughout the day. It can be taken just before, during a meal, or one hour after a meal. Capsules should be taken with water.
Xenical diet pills should be taken with a well-balanced, low-calorie diet that is rich in fruits and vegetables.
Divide your daily intake of fats, carbohydrates and proteins between three main meals. This means you should take one capsule with breakfast, one capsule with lunch, and one capsule with dinner. For maximum benefit, avoid high-fat foods such as cookies, chocolate, and savory snacks between meals.
Xenical works only in the presence of dietary fats. Therefore, if you skip a meal that does not contain fat, there is no need to take Xenical.
Tell your doctor if for some reason you do not take your medicine as prescribed. Otherwise, the doctor will be left with the impression that the treatment is not effective and will change the treatment unnecessarily.
Your doctor may stop treatment with Xenical after 12 weeks if you have not lost at least 5% weight since you started taking Xenical.
You should see weight loss within 2 weeks of starting Xenical.
Overdose
If you overdose on Xenical, contact your doctor, pharmacist, or go to the hospital as medical attention may be needed.
If you forget to take Xenical
If you forget to take your medicine, take it as soon as you remember, unless more than one hour has passed since your last meal, then resume at your usual time. Do not take double doses. If more doses are missed, please tell your doctor and follow his advice. Do not change the recommended dose without consulting your doctor.
Side effects
Like all medicines, Xenical can cause side effects.
Most of the adverse reactions associated with the use of Xenical occur as a result of a local effect on the digestive system. These symptoms are usually mild, occur at the beginning of treatment, and appear mainly after eating a high-fat meal. Usually, these symptoms disappear if you continue treatment and follow the recommended diet.
Common side effects:
Side effects that occur when using Xenical for weight loss are due to the blocking of fat. All of them, as a rule, are manifested from the gastrointestinal tract, among them:
Headache, abdominal pain and discomfort, frequent bowel movements, flatulence (gas) with secretions, fatty and loose stools, low blood sugar.
Pain in the abdomen is also not excluded. The drug does not have a harmful effect on the body, because it is not absorbed into the blood.
Other side effects:
Rectal pain and discomfort, loose stools, fecal incontinence, bloating, problems with teeth and gums, menstrual irregularities, high fatigue.
Rare side effects:
- Allergic reactions. Principal symptoms are itching, rash, urticaria, severe dyspnea, nausea, vomiting, and malaise;
- Skin blisters (including blisters that burst)
- Diverticulitis, bleeding in the rectum;
- A blood test can detect elevated levels of certain enzymes in the liver. Hepatitis (inflammation of the liver). Symptoms may include yellowing of the skin and eyes, itching, dark urine, stomach pain, and liver tenderness, sometimes with loss of appetite;
- Stones in the gallbladder. ;
- oxalate nephropathy (accumulation of calcium oxalate, which can lead to the formation of kidney stones);
- Influence on blood clotting when using anticoagulants.
Xenical(Xenical) is one of the popular drugs for weight loss Swiss pharmaceutical company F.Hoffmann-LaRoche Lt. The action of Xenical is based on blocking the work of lipase, an enzyme that promotes the breakdown of dietary fats to a level at which the body can absorb them. Xenical for weight loss is an inhibitor of gastrointestinal lipases that reduces the amount of calories absorbed by the body by preventing the absorption of some fat. The drug is not absorbed into the blood, so it does not have a harmful effect on the internal organs and is not addictive.
Indications for use of Xenical for weight loss
Xenical for weight loss prescribed to persons suffering from:
- (BMI - body mass index 25 - 30),
- obesity (BMI over 30),
- diabetes,
- arterial hypertension,
- atherosclerosis
or having a risk factor for these diseases. Reception of Xenical is combined with a moderately low-calorie diet. The drug blocks the process of splitting fats, about 30% of the fat consumed without splitting is excreted with feces. Getting less fat, the body begins to use the already accumulated reserves.
Taking Xenical first helps to stabilize the weight, then, with the full implementation of the recommendations, by 20%.
Dosage and administration
One capsule of Xenical is taken during a meal or one hour after a meal. Taking Xenical for weight loss can be skipped if there are no fats in the food.
Three capsules of Xenical (120 mg each) can be taken per day, each with a glass of water. If Xenical is missed and more than an hour has passed after a meal, the next capsule should be taken during or after the next meal. Do not take a double dose of the drug!
Taking Xenical requires a balanced diet, in which fats make up 30% of the total calorie intake. The daily rate of fat should be divided into three main meals and take Xenical for weight loss with them.
Side effects and contraindications of Xenical
Side effects when taking the drug, they appear from the intestines - profuse discharge of gases (flatulence); oily discharge from the rectum; increased frequency of bowel movements; fecal incontinence; fatty stool. There may be loose stools, discomfort or pain in the abdomen. Similar phenomena are the result of blocking fat. When the diet contains a significant amount of fat, side effects are more likely. A low-fat diet significantly reduces the chance of side effects.
Xenical contraindications- diseases of the gallbladder, chronic syndrome of impaired intestinal absorption, the period of pregnancy and breastfeeding, age up to 18 years.
Taking the drug is possible under the supervision of a doctor with diabetes mellitus, nephrolithiasis, bulimia or anorexia, taking others.
Xenical for weight loss reduces the absorption of fat-soluble vitamins, so additional intake of vitamins E, A, D, K and beta-carotene is possible. Vitamins should be taken once a day two hours after taking the drug or at bedtime.
